Dysregulated lncRNAs are associated with the progressive arterial phenotype in Hutchinson-Gilford Progeria Syndrome
Preclinical animal study indexed on 2026-08-15, with the claim calibrated to evidence grade C.
VOL. 01EST. 2026
The NewsroomMenu
The archive.
Ninety source-dated briefs reconstruct the longevity and healthy-aging record from July 17 through August 15, 2026. Historical datelines refer to the underlying source—not a false publication claim.
How to read this archive
Every brief identifies its historical source date and its actual first-publication date on Vitalspan Wire. Archive stories are excluded from Google News recency feeds.
Research file3 briefs
The microbiome in human skin aging
Research report indexed on 2026-08-15, with the claim calibrated to evidence grade C.
CT-based prediction of hematoma expansion and adverse outcomes after intracerebral hemorrhage: evidence appraisal, artificial intelligence translation, and GeroScience perspectives
Human cohort study indexed on 2026-08-15, with the claim calibrated to evidence grade B.
Research file3 briefs
Frailty transitions, depressive symptoms, and incident dementia: findings from four longitudinal studies
Human cohort study indexed on 2026-08-14, with the claim calibrated to evidence grade B.
The Shadowy Side of Aging: The Determining Role of Depression in the Development of Frailty
Research report indexed on 2026-08-14, with the claim calibrated to evidence grade C.
Nonlinear associations between exposure to natural environments and biological aging: A cohort study of middle-aged and older adults in China
Human cohort study indexed on 2026-08-14, with the claim calibrated to evidence grade B.
Research file3 briefs
Dioscorea polystachya Turcz. attenuates male reproductive aging through modulation of mTOR-Beclin-1-mediated autophagy in Leydig and Sertoli cells
Preclinical animal study indexed on 2026-08-13, with the claim calibrated to evidence grade C.
Thymus Regeneration in Countering Immunosenescence: Mechanisms, Strategies and Future Perspectives
Research review indexed on 2026-08-13, with the claim calibrated to evidence grade C.
'Healthy ageing' messaging in vaccine promotion among older adults: evaluation of vaccine intention in a survey using a social marketing methodology
Cross-sectional human study indexed on 2026-08-13, with the claim calibrated to evidence grade B.
Research file3 briefs
Dietary patterns and gut microbial clusters jointly stratify frailty in community-dwelling older Japanese adults: a cross-sectional study in the Kyotango longevity area
Cross-sectional human study indexed on 2026-08-12, with the claim calibrated to evidence grade B.
A Review of Rejuvenation Strategies Targeting Mesenchymal Stem Cell Senescence and Their Impact on Bone Health and Regeneration
Research review indexed on 2026-08-12, with the claim calibrated to evidence grade C.
Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial
Randomized human analysis indexed on 2026-08-12, with the claim calibrated to evidence grade B.
Research file3 briefs
Beyond senescence entry: individual-cell fates, population outcomes and therapeutic implications in ageing and disease
Human cohort study indexed on 2026-08-11, with the claim calibrated to evidence grade B.
Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction
Preclinical animal study indexed on 2026-08-11, with the claim calibrated to evidence grade C.
To longevity and beyond: a systems view of aging and stress resilience
Research report indexed on 2026-08-11, with the claim calibrated to evidence grade C.
Research file3 briefs
Maternal biological ageing and telomere attrition across parity, pregnancy, and the postpartum period
Human cohort study indexed on 2026-08-10, with the claim calibrated to evidence grade B.
Preserving joint healthspan in knee osteoarthritis: a geroscience-guided review of non-surgical therapies and genicular artery embolization
Randomized human analysis indexed on 2026-08-10, with the claim calibrated to evidence grade B.
Chronic subdural hematoma through the hallmarks of aging: a geroscience framework for the commonest neurosurgical condition of older adults
Randomized human analysis indexed on 2026-08-10, with the claim calibrated to evidence grade B.
Research file3 briefs
Defying Expectations: Extended Lifespan and Age-Related Telomere Dynamics in the Tropical Bat Species, Molossus molossus
Preclinical animal study indexed on 2026-08-09, with the claim calibrated to evidence grade C.
Multidomain perioperative physiological vulnerability, longitudinal recovery patterns, and clinical outcomes after gastrointestinal cancer surgery in older adults
Human cohort study indexed on 2026-08-09, with the claim calibrated to evidence grade B.
Time-Restricted Feeding Prevents Cardiac Aging by Entraining Gut Microbiota Clock and Promoting Diurnal Rhythm Autophagy in Prediabetic Mice
Preclinical animal study indexed on 2026-08-09, with the claim calibrated to evidence grade C.
Research file3 briefs
Body composition-defined sarcopenia phenotypes, diabetes complications, and CGM-derived glycemic profiles in frail older adults with diabetes: a cross-sectional study
Human cohort study indexed on 2026-08-08, with the claim calibrated to evidence grade B.
Effects of intrinsic capacity on health-related outcomes are moderated by frailty status among community-dwelling older adults
Human cohort study indexed on 2026-08-08, with the claim calibrated to evidence grade B.
Corpus callosum fractional anisotropy from routine diffusion tensor imaging predicts dementia in older adults beyond clinical risk factors
Human cohort study indexed on 2026-08-08, with the claim calibrated to evidence grade B.
Research file3 briefs
From Stigma to Frailty-Psychosocial Pathways Among People Aging With HIV in China: A Cross-Sectional Study
Cross-sectional human study indexed on 2026-08-07, with the claim calibrated to evidence grade B.
Toward a Context-Aware Geroscience: Integrating Structural and Social Context into Aging Biology
Research report indexed on 2026-08-07, with the claim calibrated to evidence grade C.
Psychological adversities and epigenetic ageing in midlife and older age: A systematic review and meta-analysis
Systematic review and meta-analysis indexed on 2026-08-07, with the claim calibrated to evidence grade B.
Research file3 briefs
The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions
Research report indexed on 2026-08-06, with the claim calibrated to evidence grade C.
Imaging-Based Markers of Sarcopenia in Lower Limb Ischemia: A Systematic Review
Human cohort study indexed on 2026-08-06, with the claim calibrated to evidence grade B.
STING deficiency does not rescue short telomere-mediated aging phenotypes and longevity in TERC- or TERT-telomerase deficient mice
Human cohort study indexed on 2026-08-06, with the claim calibrated to evidence grade B.
Research file3 briefs
Convergent Gut Microbiome Remodeling Across Ischemic Stroke, Myocardial Infarction, and Longevity Reveals a Shared Ecological Signature of Aging and Disease
Human cohort study indexed on 2026-08-05, with the claim calibrated to evidence grade B.
Partnerships and practices: a scoping review of engaging older adults living with frailty in the research process
Systematic review indexed on 2026-08-05, with the claim calibrated to evidence grade B.
Hepatic SIRT6 Deficiency Accelerates Female-Specific Aging Through SULT1E1-Mediated Estrogen Depletion
Human cohort study indexed on 2026-08-05, with the claim calibrated to evidence grade B.
Research file3 briefs
Effects of digital health-based exercise interventions on older adults with sarcopenia: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Systematic review and meta-analysis indexed on 2026-08-04, with the claim calibrated to evidence grade B.
Motor-Sparing Regional Analgesia in Frail and Sarcopenic Older Adults Undergoing Total Knee Arthroplasty: From Anatomy to Clinical Decision-Making-A Narrative Review
Randomized human analysis indexed on 2026-08-04, with the claim calibrated to evidence grade B.
Association between changes in working status and frailty across different types of employment: a longitudinal study in Korea, the world's most rapidly ageing nation
Human cohort study indexed on 2026-08-04, with the claim calibrated to evidence grade B.
Research file3 briefs
Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer's Neuropathology but Are Not Independently Related to Dementia
Research report indexed on 2026-08-03, with the claim calibrated to evidence grade C.
Ambient temperature and 24-hour movement behaviors in community-dwelling older adults in Japan: The Kyotango Longevity Cohort Study
Human cohort study indexed on 2026-08-03, with the claim calibrated to evidence grade B.
Mitochondrial Inflammation and Muscle Aging: Targeting the Inflammatory Microenvironment in Sarcopenic Muscle
Research review indexed on 2026-08-03, with the claim calibrated to evidence grade C.
Research file3 briefs
Brain aging clocks: From methodological advances to cellular mechanisms
Human cohort study indexed on 2026-08-02, with the claim calibrated to evidence grade B.
Vitamin D as a Modulator of Sarcopenia in Women: Interactions with Dietary Patterns and Physical Exercise
Research review indexed on 2026-08-02, with the claim calibrated to evidence grade C.
Muscle Strength as a Key Independent Predictor of Arterial Stiffness and Metabolic Syndrome in Aging Mexicans: Unveiling the Sarcopenic Obesity Paradox
Human cohort study indexed on 2026-08-02, with the claim calibrated to evidence grade B.
Research file3 briefs
Extracellular vesicles and epigenetic aging clocks in tissue aging: an exosome-focused conceptual framework with a focus on skin
Research review indexed on 2026-08-01, with the claim calibrated to evidence grade C.
Metformin: A Promising Candidate for Slowing the Progression of Cardiovascular Aging
Randomized human analysis indexed on 2026-08-01, with the claim calibrated to evidence grade B.
Community-Based Approaches to Oral Frailty for Healthy Longevity in Japan: Bridging Screening, Community Action, and Integrated Care
Research review indexed on 2026-08-01, with the claim calibrated to evidence grade C.
Research file3 briefs
Independent and combined effects of sarcopenia and physical frailty on the incident functional disabilities in community-dwelling older adults: A 6-year prospective study
Human cohort study indexed on 2026-07-31, with the claim calibrated to evidence grade B.
Traditional Chinese medicine for frailty and sarcopenia in aging populations: a bibliometric and visualized analysis of research trajectories and emerging frontiers
Systematic review and meta-analysis indexed on 2026-07-31, with the claim calibrated to evidence grade B.
Gut Microbiota-Targeted Nutrition for Healthy Aging: Mechanistic Roles of Polyphenols and Dietary Fiber in Geroscience
Randomized human analysis indexed on 2026-07-31, with the claim calibrated to evidence grade B.
Research file3 briefs
Predictive Risk Models for Frailty Onset in Older Adults: A Scoping Review of Methodological Trends, Model Performance, and Clinical Translation Gap
Human cohort study indexed on 2026-07-30, with the claim calibrated to evidence grade B.
Diagnosed oral cavity and salivary gland disorders and the risk of incident Parkinson disease, Alzheimer disease, dementia and all-cause mortality: a retrospective cohort study
Human cohort study indexed on 2026-07-30, with the claim calibrated to evidence grade B.
Three-dimensional ultrasound shape analysis reveals distinct structural patterns in muscle aging and sarcopenia
Research report indexed on 2026-07-30, with the claim calibrated to evidence grade C.
Research file3 briefs
Complosome as a key modulator of cellular senescence, aging and age-related diseases
Human cohort study indexed on 2026-07-29, with the claim calibrated to evidence grade B.
Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations
Research report indexed on 2026-07-29, with the claim calibrated to evidence grade C.
Sensory impairment, epigenetic ageing, and later-life functional decline and mortality in older adults
Cross-sectional human study indexed on 2026-07-29, with the claim calibrated to evidence grade B.
Research file3 briefs
Genetic association of immunosenescence to immune decline
Research review indexed on 2026-07-28, with the claim calibrated to evidence grade C.
Roles of microRNA in aging and dietary restriction-induced longevity
Research review indexed on 2026-07-28, with the claim calibrated to evidence grade C.
FDA redraws the development path for 17 generic peptide products
Authoritative regulatory record indexed on 2026-07-28, with the claim calibrated to evidence grade A.
Research file3 briefs
Aging-related metabolic dysregulation in osteoporosis: mechanisms and therapeutic strategies
Research review indexed on 2026-07-27, with the claim calibrated to evidence grade C.
Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation
Research report indexed on 2026-07-27, with the claim calibrated to evidence grade C.
Exploring the exposome and unexplained variance in epigenetic ageing - Insights from a longitudinal twin study in adolescence and early adulthood
Human cohort study indexed on 2026-07-27, with the claim calibrated to evidence grade B.
Research file3 briefs
Medical Challenges in Caring for Older Adults With Type 2 Diabetes and Dementia: A Qualitative Interview Study Using SCAT to Compare Primary Care Physicians and Diabetes Specialists in Japan
Human cohort study indexed on 2026-07-26, with the claim calibrated to evidence grade B.
Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults-A Narrative Review
Research review indexed on 2026-07-26, with the claim calibrated to evidence grade C.
A Low-Data-Burden Vascular-Behavioral Profile for First-Pass Stratification of Later-Life Cognitive Decline Across International Aging Cohorts
Human cohort study indexed on 2026-07-26, with the claim calibrated to evidence grade B.
Research file3 briefs
Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway
Preclinical animal study indexed on 2026-07-25, with the claim calibrated to evidence grade C.
Beyond the linear genome: how reference bias threatens preventive medicine and geroscience
Research report indexed on 2026-07-25, with the claim calibrated to evidence grade C.
Bilingualism and Cognitive Aging in Ethnically Diverse Older Adults: Cross-sectional and Longitudinal Evidence from HABS-HD
Human cohort study indexed on 2026-07-25, with the claim calibrated to evidence grade B.
Research file3 briefs
Epitalon’s longevity reputation meets FDA’s compounding test
Authoritative regulatory record indexed on 2026-07-24, with the claim calibrated to evidence grade A.
Semax compounding review puts neuropeptide claims against the federal record
Authoritative regulatory record indexed on 2026-07-24, with the claim calibrated to evidence grade A.
FDA reviews emideltide claims for sleep disorders and opioid withdrawal
Authoritative regulatory record indexed on 2026-07-24, with the claim calibrated to evidence grade A.
Research file3 briefs
MOTS-c and TB-500 face the evidence standards of FDA compounding review
Authoritative regulatory record indexed on 2026-07-23, with the claim calibrated to evidence grade A.
KPV enters FDA advisory review with wound-healing claims under scrutiny
Authoritative regulatory record indexed on 2026-07-23, with the claim calibrated to evidence grade A.
FDA panel takes up BPC-157 as compounding evidence comes under review
Authoritative regulatory record indexed on 2026-07-23, with the claim calibrated to evidence grade A.
Research file3 briefs
Older Adults' Perceptions of the Ageing Experience in Trinidad and Tobago: A Qualitative Study
Research report indexed on 2026-07-22, with the claim calibrated to evidence grade C.
The Microbiome-Mitochondria Axis in aging: a self-reinforcing vicious cycle linking metabolic dysregulation, mitochondrial quality control failure, and inflammaging
Research review indexed on 2026-07-22, with the claim calibrated to evidence grade C.
The PERK paradox in aging: how ER stress shapes senescence and neurodegeneration
Research review indexed on 2026-07-22, with the claim calibrated to evidence grade C.
Research file3 briefs
Oral Aging in Older Adults: Mechanisms, Assessment and Clinical Relevance in Gerodontology: A Narrative Review
Research review indexed on 2026-07-21, with the claim calibrated to evidence grade C.
A metabolomic clock of population ageing: cross-cohort validation and associations with frailty and cognitive function
Human cohort study indexed on 2026-07-21, with the claim calibrated to evidence grade B.
Immunosenescence shapes the tumor immune microenvironment and limits PD-1/PD-L1 blockade efficacy in older patients with cancer
Research review indexed on 2026-07-21, with the claim calibrated to evidence grade C.
Research file3 briefs
Social frailty independently predicts 9-year mortality among community-dwelling older adults in Mexico: validation of a brief social frailty index
Research report indexed on 2026-07-20, with the claim calibrated to evidence grade C.
Radiofrequency technology as an anti-aging intervention: clinical efficacy in reversing senescence-driven skin laxity and age-related dermal degeneration
Research report indexed on 2026-07-20, with the claim calibrated to evidence grade C.
Vitamin D and frailty: Clinical evidence, mechanistic insights, and translational challenges
Randomized human analysis indexed on 2026-07-20, with the claim calibrated to evidence grade B.
Research file3 briefs
Rethinking frailty as a disorder of mitochondrial adaptability, from energetic congestion to systemic vulnerability
Research report indexed on 2026-07-19, with the claim calibrated to evidence grade C.
Phytochemicals modulating HSF-1-associated pathways: A systematic review of longevity-extending mechanisms in Caenorhabditis elegans
Systematic review indexed on 2026-07-19, with the claim calibrated to evidence grade B.
Associations Between 24-h Movement Behavior Composition and Muscle Health in Community-Dwelling Older Adults: The Kyotango Longevity Cohort Study
Human cohort study indexed on 2026-07-19, with the claim calibrated to evidence grade B.
Research file3 briefs
Biological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study
Human cohort study indexed on 2026-07-18, with the claim calibrated to evidence grade B.
TTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence
Research report indexed on 2026-07-18, with the claim calibrated to evidence grade C.
Neurovascular unit senescence as a driver of blood-brain barrier dysfunction in Alzheimer's disease：Mechanisms, consequences, and therapeutic implications
Research review indexed on 2026-07-18, with the claim calibrated to evidence grade C.
Research file3 briefs
Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice
Preclinical animal study indexed on 2026-07-17, with the claim calibrated to evidence grade C.
Disruption of CDK4/6-RARα-NF-κB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy
Preclinical animal study indexed on 2026-07-17, with the claim calibrated to evidence grade C.
Longitudinal associations between movement and sarcopenia, gait speed, and grip strength differ by frailty level in the Canadian Longitudinal Study on Aging
Human cohort study indexed on 2026-07-17, with the claim calibrated to evidence grade B.