LongevityVitalspan Wire conceptual illustrationFrailty transitions, depressive symptoms, and incident dementia: findings from four longitudinal studies
Human cohort study indexed on 2026-08-14, with the claim calibrated to evidence grade B.
VOL. 01AUGUST 2026
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Longevity
The biology of aging, clinical translation and the hard work of separating a longer life from a longer claim.
LongevityVitalspan Wire conceptual illustrationLongevityVitalspan Wire conceptual illustrationThe Shadowy Side of Aging: The Determining Role of Depression in the Development of Frailty
Research report indexed on 2026-08-14, with the claim calibrated to evidence grade C.
LongevityVitalspan Wire conceptual illustrationNonlinear associations between exposure to natural environments and biological aging: A cohort study of middle-aged and older adults in China
Human cohort study indexed on 2026-08-14, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustration'Healthy ageing' messaging in vaccine promotion among older adults: evaluation of vaccine intention in a survey using a social marketing methodology
Cross-sectional human study indexed on 2026-08-13, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationDietary patterns and gut microbial clusters jointly stratify frailty in community-dwelling older Japanese adults: a cross-sectional study in the Kyotango longevity area
Cross-sectional human study indexed on 2026-08-12, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationTo longevity and beyond: a systems view of aging and stress resilience
Research report indexed on 2026-08-11, with the claim calibrated to evidence grade C.
LongevityVitalspan Wire conceptual illustrationPreserving joint healthspan in knee osteoarthritis: a geroscience-guided review of non-surgical therapies and genicular artery embolization
Randomized human analysis indexed on 2026-08-10, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationChronic subdural hematoma through the hallmarks of aging: a geroscience framework for the commonest neurosurgical condition of older adults
Randomized human analysis indexed on 2026-08-10, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationMultidomain perioperative physiological vulnerability, longitudinal recovery patterns, and clinical outcomes after gastrointestinal cancer surgery in older adults
Human cohort study indexed on 2026-08-09, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationBody composition-defined sarcopenia phenotypes, diabetes complications, and CGM-derived glycemic profiles in frail older adults with diabetes: a cross-sectional study
Human cohort study indexed on 2026-08-08, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationEffects of intrinsic capacity on health-related outcomes are moderated by frailty status among community-dwelling older adults
Human cohort study indexed on 2026-08-08, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationCorpus callosum fractional anisotropy from routine diffusion tensor imaging predicts dementia in older adults beyond clinical risk factors
Human cohort study indexed on 2026-08-08, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationFrom Stigma to Frailty-Psychosocial Pathways Among People Aging With HIV in China: A Cross-Sectional Study
Cross-sectional human study indexed on 2026-08-07, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationImaging-Based Markers of Sarcopenia in Lower Limb Ischemia: A Systematic Review
Human cohort study indexed on 2026-08-06, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationSTING deficiency does not rescue short telomere-mediated aging phenotypes and longevity in TERC- or TERT-telomerase deficient mice
Human cohort study indexed on 2026-08-06, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationConvergent Gut Microbiome Remodeling Across Ischemic Stroke, Myocardial Infarction, and Longevity Reveals a Shared Ecological Signature of Aging and Disease
Human cohort study indexed on 2026-08-05, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationPartnerships and practices: a scoping review of engaging older adults living with frailty in the research process
Systematic review indexed on 2026-08-05, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationEffects of digital health-based exercise interventions on older adults with sarcopenia: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Systematic review and meta-analysis indexed on 2026-08-04, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationMotor-Sparing Regional Analgesia in Frail and Sarcopenic Older Adults Undergoing Total Knee Arthroplasty: From Anatomy to Clinical Decision-Making-A Narrative Review
Randomized human analysis indexed on 2026-08-04, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationAssociation between changes in working status and frailty across different types of employment: a longitudinal study in Korea, the world's most rapidly ageing nation
Human cohort study indexed on 2026-08-04, with the claim calibrated to evidence grade B.
LongevityVitalspan Wire conceptual illustrationThe hallmarks of aging are a map, not a treatment menu
How to read one of longevity science's most influential frameworks without turning mechanisms into prescriptions.