The newest reporting from every desk, ordered by publication time. New stories appear here immediately after publication.
Restoring the youth-associated protein TIMP2 changed inflammatory and debris-clearing features of microglia in aged mice. The experiments identify a possible brain-aging pathway, not a treatment shown to preserve cognition or prevent neurodegenerative disease in people.
An analysis of 407 ADNI participants linked a lower DTI-ALPS index with tau-PET burden and selected blood biomarkers. The finding supports further study of brain-fluid dynamics but does not validate the MRI measure as a diagnostic test or direct reading of glymphatic clearance.
A large UK Biobank analysis connects higher circulating glycine with lower calculated biological age and less inflammatory and oxidative stress. The observational design cannot show that glycine—or a supplement containing it—slows aging.
The August 12 complaints target peptide vendors, a compounding pharmacy and a medical spa accused of selling retatrutide before regulatory approval. The litigation adds private enforcement pressure to FDA’s existing prohibition on compounding the investigational drug.
A clinical review separates established teriparatide use from experimental antimicrobial, cartilage-penetrating and AI-designed peptide platforms.
IDR-1002 reduced inflammatory markers, supported mineralization and improved tissue organization in laboratory and rat pulpitis experiments.
The modular system paired a HER2-targeting engager with localized IL-12, producing stronger immune responses in a model tumor environment.
The candidate reduced a METTL3-METTL14 interaction signal and cellular m6A levels, but all antitumor evidence remains in vitro.
Structure-based screening produced a micromolar-binding candidate with target-dependent antiproliferative activity across several prostate cancer cell lines.
The experimental nanostructure activated Nrf2 in retinal pigment epithelium and preserved retinal integrity for 28 days after one intravitreal injection.
The galanin-family neuropeptide shifted energy balance after central administration and produced an acute intranasal signal in male rats.
C3 inhibition reduced astrocyte loss, aquaporin-4 depletion and demyelination in experimental neuromyelitis optica spectrum disorder.